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Study identifier: NCT06077760 Synced from ClinicalTrials.gov · August 02, 2026
● Recruiting

A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)

Condition: Non-small Cell Lung Cancer  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 3
Planned participants868
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this study is to evaluate intismeran autogene plus pembrolizumab versus placebo plus pembrolizumab for the adjuvant treatment of margin negative, completely resected Stage II, IIIA, IIIB (with nodal involvement \[N2\]) non-small cell lung cancer (NSCLC). The primary hypothesis is that intismeran autogene plus pembrolizumab is superior to placebo plus pembrolizumab with respect to disease-free survival (DFS) as assessed by the investigator.

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

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Locations (229)

Alaska Oncology and Hematology ( Site 0039)Anchorage, Alaska, United StatesRecruiting
The University of Arizona Cancer Center - North Campus ( Site 0071)Tucson, Arizona, United StatesRecruiting
YUMA REGIONAL MEDICAL CENTER CANCER CENTER ( Site 0020)Yuma, Arizona, United StatesCompleted
UCLA Clinical & Translational Research Center (CTRC) ( Site 0059)Los Angeles, California, United StatesRecruiting
Hoag Memorial Hospital Presbyterian ( Site 4042)Newport Beach, California, United StatesRecruiting
Hoag Memorial Hospital Presbyterian ( Site 4048)Newport Beach, California, United StatesRecruiting
St. Joseph Hospital-The Center for Cancer Prevention and Treatment ( Site 0074)Orange, California, United StatesRecruiting
University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 0030)Orange, California, United StatesRecruiting
UCHealth Memorial Hospital-Heme Onc ( Site 0052)Colorado Springs, Colorado, United StatesCompleted
George Washington University Medical Faculty Associates ( Site 4064)Washington D.C., District of Columbia, United StatesRecruiting
Mayo Clinic Florida ( Site 4043)Jacksonville, Florida, United StatesRecruiting
Miami Cancer Institute at Baptist Health, Inc. ( Site 4047)Miami, Florida, United StatesRecruiting

+ 217 more locations — full list on the registry record.

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