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Study identifier: NCT06067737 Synced from ClinicalTrials.gov · July 30, 2026
● Recruiting

Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder

Condition: Opioid Use Disorder  ·  Sponsor: Johns Hopkins University

PhasePhase 2
Planned participants90
Who can joinAll sexes, 21 Years to 70 Years
Healthy volunteersNo

About this study

This study will examine the effect of a single high dose of psilocybin therapy (30 mg) versus a very low dose (1 mg) as an adjunctive therapy to individuals undergoing standard-of-care outpatient buprenorphine treatment for Opioid use disorder (OUD). The participants will have previously undergone buprenorphine induction before. Effects of adjunctive psilocybin will be determined for longitudinal outcomes of opioid abstinence, compliance with outpatient buprenorphine maintenance, quality of life, and mood.

This description comes directly from the study's public registry record.

Talk to the study team

Andrew L Gaddis, MD  ·  410-550-0048  ·  gaddis@jhmi.edu

Sandeep Nayak, MD  ·  410-550-0048  ·  smn@jhmi.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Johns Hopkins Center for Psychedelic and Consciousness ResearchBaltimore, Maryland, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06067737