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Study identifier: NCT05932589 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Neurophysiologic Biomarkers in Rett Syndrome

Condition: Rett Syndrome · RTT · Rett Syndrome, Atypical  ·  Sponsor: Children's Hospital of Philadelphia

PhaseN/A
Planned participants202
Who can joinFemale, 1 Year to 18 Years
Healthy volunteersYes

About this study

The goal of this observational study is to identify candidate biomarkers in individuals with Rett Syndrome (RTT). The main questions it aims to answer are: * Do these biomarkers change during clinical changes in individuals with RTT? * Are biomarkers stable over time in clinically stable individuals? * Do these biomarkers correlate with severity of RTT? Participants will be asked to undergo an electroencephalogram (EEG) with measurements of Evoked Potentials (EP) to measure electrical activity in the brain. Researchers will compare findings in individuals with RTT to those in typically developing individuals to see if there are differences between the two groups.

This description comes directly from the study's public registry record.

Talk to the study team

Holly Dubbs, MS. CGC  ·  215-590-1719  ·  dubbsh@chop.edu

Always discuss trial participation with your own doctor first.

Locations (6)

Children's Hospital of Los AngelesLos Angeles, California, United StatesRecruiting
Children's Hospital ColoradoAurora, Colorado, United StatesRecruiting
Boston Children's HospitalBrookline, Massachusetts, United StatesRecruiting
Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania, United StatesRecruiting
Vanderbilt University Medical CenterNashville, Tennessee, United StatesRecruiting
Texas Children's HospitalHouston, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05932589