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Study identifier: NCT05882734 Synced from ClinicalTrials.gov · August 04, 2026
● Active Not Recruiting

Tuvusertib (M1774) in Combination With Cemiplimab in Participants With Non-Squamous NSCLC (DDRiver NSCLC 322)

Condition: Non-Small Cell Lung Cancer  ·  Sponsor: EMD Serono Research & Development Institute, Inc.

PhasePhase 1/Phase 2
Planned participants61
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is an Open-label, multicenter clinical study conducted in two Phases to establish the efficacy, safety, tolerability, and pharmacokinetics of the ataxia telangiectasia mutated and Rad3-related protein kinase (ATR) inhibitor Tuvusertib in Combination with Cemiplimab in Participants with Non-Squamous Non-Small Cell Lung Cancer (nsqNSCLC) that has Progressed on Prior Anti-PD-(L)1 and Platinum-based Therapies..

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

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Locations (54)

UCLA Hematology and Oncology - Santa MonicaSanta Monica, California, United States
UPMC Cancer CenterPittsburgh, Pennsylvania, United States
Tennessee Cancer Specialists - Biomedical ResearchKnoxville, Tennessee, United States
The University of Texas MD Anderson Cancer CenterHouston, Texas, United States
Millennium Research & Clinical DevelopmentHouston, Texas, United States
Virginia Cancer Specialists, PCFairfax, Virginia, United States
Institut Jules Bordet - Department of Institut Jules Bordet'Anderlecht, Belgium
UZA - OncologyEdegem, Belgium
Jessa Ziekenhuis HospitalHasselt, Belgium
Universitair Ziekenhuis Brussel - UZBJette, Belgium
UZ LeuvenLeuven, Belgium
CHU de Liège - PARENTLiège, Belgium

+ 42 more locations — full list on the registry record.

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