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A Study to Learn How Well a Higher Amount of Aflibercept Given as an Injection Into the Eye Works and How Safe it is in People With Reduced Vision Due to Swelling in the Macula, Central Part of the Retina Caused by a Blocked Vein in the Retina (Macula Edema Secondary to Retinal Vein Occlusion)
Condition: Macular Edema Secondary to Retinal Vein Occlusion · Sponsor: Bayer
About this study
Researchers are looking for a better way to treat people who have macular edema secondary to retinal vein occlusion (RVO). In people with RVO, a blood vessel that carries blood away from the retina (vein) becomes blocked. The retina is the very back part of the eye. The blocked vein causes fluid and blood to leak into the retina and thereby causes a swelling of the macula (the center of the retina responsible for fine vision). This swelling is called macular edema. When a vein in the retina is blocked, the levels of a protein called vascular endothelial growth factor (VEGF) rises. VEGF helps the growth of new blood vessels. This can lead to macular edema and may cause the vision to become blurry. The study treatment intravitreal (IVT) aflibercept is given as an injection into the eye. It works by blocking VEGF and this can help repair vision problems related to RVO. IVT aflibercept is already available and is prescribed by doctors as the standard of care treatment for macula edema secondary to RVO. Standard of care is a treatment that medical experts consider most appropriate for a disease. Standard of care is given every 4 weeks in people with macula edema secondary to RVO. While repeated injections of aflibercept may prevent worsening of vision, it may place a burden on the patient. However, a higher amount (8 mg) compared to the standard of care (2 mg) of IVT aflibercept is being tested in studies. This higher amount could be given less often. The amount of IVT afliber…
This description comes directly from the study's public registry record.
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Locations (273)
| Retina Consultants of Orange County - Fullerton | Fullerton, California, United States | — |
| South Coast Retina - Long Beach | Long Beach, California, United States | — |
| Northern California Retina Vitreous Associates - Mountain View Office | Mountain View, California, United States | — |
| Desert Retina Consultants - Palm Springs Office | Palm Springs, California, United States | — |
| Azul Vision Pasadena | Pasadena, California, United States | — |
| Retina Consultants of Southern California | Redlands, California, United States | — |
| Retina Consultants of Southern Colorado, PC | Colorado Springs, Colorado, United States | — |
| New England Retina Associates | New London, Connecticut, United States | — |
| Rand Eye Institute | Deerfield Beach, Florida, United States | — |
| National Ophthalmic Research Institute - Fort Myers | Fort Myers, Florida, United States | — |
| The Eye Institute of West Florida - Largo | Largo, Florida, United States | — |
| Florida Eye Associates - Melbourne Main Office | Melbourne, Florida, United States | — |
+ 261 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05850520