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A Study to Learn How Well Dupilumab Works in Adult and Adolescent Participants With Eosinophilic Gastritis With or Without Eosinophilic Duodenitis and the Side Effects it May Have
Condition: Eosinophilic Gastritis (EoG) · Eosinophilic Duodenitis (EoD) · Eosinophilic Gastrointestinal Disease (EGID) · Sponsor: Regeneron Pharmaceuticals
About this study
This study is researching an experimental drug called dupilumab. The study is focused on participants with active eosinophilic gastritis (EoG) with or without eosinophilic duodenitis (EoD). Participants with EoD only are not eligible for enrollment. EoG and EoD are uncommon, persistent, allergic/immune diseases in which eosinophils (a type of white blood cell) gather in large numbers in the stomach and small intestine and cause inflammation and damage. The aim of the study is to evaluate the effect of dupilumab on relieving EoG (with or without EoD) symptoms and reducing inflammation in the stomach and, if applicable, small intestine in adults and adolescents aged 12 years and older after at least 24 weeks (about 6 months) and up to 52 weeks (1 year) of treatment. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)
This description comes directly from the study's public registry record.
Talk to the study team
No contact information is available for this study as per the public registry record.
Always discuss trial participation with your own doctor first.
Locations (53)
| Phoenix Childrens Hospital | Phoenix, Arizona, United States | — |
| Om Research LLC | Apple Valley, California, United States | — |
| Scripps Clinic | La Jolla, California, United States | — |
| Om Research LLC | Lancaster, California, United States | — |
| University of California - Los Angeles (UCLA) | Los Angeles, California, United States | — |
| University of Southern California Keck School of Medicine | Los Angeles, California, United States | — |
| GastroIntestinal BioSciences | Los Angeles, California, United States | — |
| United Medical Doctors | Murrieta, California, United States | — |
| Ucsf Medical Center (Benioff Childrens Hospital) | San Francisco, California, United States | — |
| University of Colorado Anschutz Health Science Building (AHSB) CU Research Pharmacy | Aurora, Colorado, United States | — |
| Connecticut Clinical Research Institute | Bristol, Connecticut, United States | — |
| UConn Health | Farmington, Connecticut, United States | — |
+ 41 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05831176