Condition: Acute HIV Infection · Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
A5388 is a phase II, two-arm, randomized, double-blind, placebo-controlled study that will enroll 48 antiretroviral therapy (ART)-naïve adults with acute HIV infection (AHI) in order to determine whether: * Administration of combination HIV-specific broadly neutralizing antibody (bNAb) therapy in addition to ART during acute HIV infection (AHI) will be safe. * Participants who receive combination bNAb therapy in addition to ART during AHI will be more likely to demonstrate a delay in time to HIV-1 RNA ≥1,000 copies/mL for 4 consecutive weeks compared to participants who receive placebo plus ART. * Participants who receive combination bNAb therapy in addition to ART during AHI will demonstrate lower viral reservoirs and enhanced HIV-specific immunity compared to participants who receive placebo plus ART.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| 31788, Alabama CRS | Birmingham, Alabama, United States | Not Yet Recruiting |
| 1201, University of Southern California CRS | Los Angeles, California, United States | Not Yet Recruiting |
| 601, University of California, Los Angeles CARE Center CRS | Los Angeles, California, United States | Not Yet Recruiting |
| 701, UCSD Antiviral Research Center CRS | San Diego, California, United States | Not Yet Recruiting |
| 801, University of California, San Francisco HIV/AIDS CRS | San Francisco, California, United States | Not Yet Recruiting |
| 603, Harbor University of California Los Angeles Center CRS | Torrance, California, United States | Not Yet Recruiting |
| 6101, University of Colorado Hospital CRS | Aurora, Colorado, United States | Recruiting |
| 31791, Whitman-Walker Institute, Inc. CRS | Washington D.C., District of Columbia, United States | Not Yet Recruiting |
| 5802, The Ponce de Leon Center CRS | Atlanta, Georgia, United States | Recruiting |
| 2701, Northwestern University CRS | Chicago, Illinois, United States | Not Yet Recruiting |
| 2702, Rush University CRS | Chicago, Illinois, United States | Not Yet Recruiting |
| 201, Johns Hopkins University CRS | Baltimore, Maryland, United States | Not Yet Recruiting |
+ 24 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05719441