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Beta-lactam Intermittent Versus Continuous Infusion and Combination Antibiotic Therapy in Sepsis
Condition: Sepsis · Sponsor: Assistance Publique - Hôpitaux de Paris
About this study
Patients hospitalized in ICU with sepsis (infection with life-threatening organ dysfunction according to sepsis 3.0 definitions) or septic shock presumably due to MDR-GNB (multidrug resistant Gram-negative bacteria). The study will be a prospective multicentre, randomized, open-label comparative continuous vs. intermittent pivotal βL (Beta Lactamine) antibiotic infusion strategies and combination vs. monotherapy trial conducted with a 2X2 factorial design.
This description comes directly from the study's public registry record.
Talk to the study team
Jean-François TIMSIT, MD-PhD · 01.40.25.77.07 · jean-françois.timsit@aphp.fr
Lila BOUADMA, MD-PhD · 01.40.25.77.07 · lila.bouadma@aphp.fr
Always discuss trial participation with your own doctor first.
Locations (28)
| Médecine intensive - réanimation - CHU Amiens-Picardie | Amiens, France | Withdrawn |
| Réanimation polyvalente - CH d'Argenteuil - Hôpital Victor Dupuy | Argenteuil, France | Recruiting |
| Réanimation polyvalente - CH Avignon | Avignon, France | Recruiting |
| Médecine intensive - réanimation - CHU Bordeaux - Hôpital Pellegrin | Bordeaux, France | Recruiting |
| Médecine intensive - réanimation - Ambroise Paré | Boulogne-Billancourt, France | Recruiting |
| Médecine intensive - réanimation - CHU Gabriel Montpied | Clermont-Ferrand, France | Recruiting |
| Anesthésie - Réanimation - Beaujon | Clichy, France | Recruiting |
| Réanimation polyvalente/Surveillance continue - CH Sud Essonne-Etampes | Étampes, France | Recruiting |
| Médecine intensive - réanimation-Centre Hospitalier Départemental Vendée | La Roche-sur-Yon, France | Recruiting |
| Médecine intensive - réanimation - CHU Grenoble-Alpes Hôpital Michallon | La Tronche, France | Recruiting |
| Réanimation polyvalente - CH de Versailles - Hôpital André Mignot | Le Chesnay, France | Recruiting |
| Réanimation Médico Chirurgicale & USC - CH Le Mans | Le Mans, France | Recruiting |
+ 16 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05681442