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Venetoclax in Combination With ASTX727 for the Treatment of Chronic Myelomonocytic Leukemia and Other Myelodysplastic Syndrome/Myeloproliferative Neoplasm
Condition: Chronic Myelomonocytic Leukemia · Myelodysplastic Syndrome · Myelodysplastic Syndrome With Excess Blasts · Sponsor: National Cancer Institute (NCI)
About this study
This phase II trial tests whether decitabine and cedazuridine (ASTX727) in combination with venetoclax work better than ASTX727 alone at decreasing symptoms of bone marrow cancer in patients with chronic myelomonocytic leukemia (CMML), myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN) with excess blasts. Blasts are immature blood cells. Decitabine is in a class of medications called hypomethylation agents. It works by helping the bone marrow produce normal blood cells and by killing abnormal cells in the bone marrow. Cedazuridine is in a class of medications called cytidine deaminase inhibitors. It prevents the breakdown of decitabine, making it more available in the body so that decitabine will have a greater effect. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. The combination of ASTX727 and venetoclax may be more effective in reducing the cancer signs and symptoms in patients with CMML, or MDS/MPN with excess blasts.
This description comes directly from the study's public registry record.
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No contact information is available for this study as per the public registry record.
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Locations (34)
| Mayo Clinic Hospital in Arizona | Phoenix, Arizona, United States | — |
| UC Irvine Health Cancer Center-Newport | Costa Mesa, California, United States | — |
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care | Irvine, California, United States | — |
| UCI Health Laguna Hills | Laguna Hills, California, United States | — |
| Los Angeles General Medical Center | Los Angeles, California, United States | — |
| USC / Norris Comprehensive Cancer Center | Los Angeles, California, United States | — |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange, California, United States | — |
| University of California Davis Comprehensive Cancer Center | Sacramento, California, United States | — |
| Yale University | New Haven, Connecticut, United States | — |
| Mayo Clinic in Florida | Jacksonville, Florida, United States | — |
| Northwestern University | Chicago, Illinois, United States | — |
| University of Chicago Comprehensive Cancer Center | Chicago, Illinois, United States | — |
+ 22 more locations — full list on the registry record.
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