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Study identifier: NCT05488314 Synced from ClinicalTrials.gov · August 02, 2026
● Active Not Recruiting

A Study of Amivantamab and Capmatinib Combination Therapy in Unresectable Metastatic Non-small Cell Lung Cancer

Condition: Carcinoma, Non-Small-Cell Lung  ·  Sponsor: Janssen Research & Development, LLC

PhasePhase 1/Phase 2
Planned participants57
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to identify the recommended Phase 2 combination dose (RP2CD\[s\]) of the amivantamab and capmatinib combination therapy in participants with non-small cell lung cancer (NSCLC) in Phase 1 (combination dose selection), and to evaluate the antitumor effect of the amivantamab and capmatinib combination therapy in mesenchymal-epithelial transition (MET) exon 14 skipping mutation and MET amplified NSCLC, when administered at the selected RP2CD(s) in Phase 2 (expansion).

This description comes directly from the study's public registry record.

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No contact information is available for this study as per the public registry record.

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Locations (78)

University of Alabama at Birmingham, Comprehensive Cancer CenterBirmingham, Alabama, United States
The Oncology Institute of Hope and InnovationCerritos, California, United States
UCLALos Angeles, California, United States
Montefiore Einstein Center for Cancer CareThe Bronx, New York, United States
Virginia Cancer SpecialistsFairfax, Virginia, United States
PERSONAL Oncologia de Precisao e PersonalizadaBelo Horizonte, Brazil
CIONC Centro Integrado de Oncologia de CuritibaCuritiba, Brazil
UPCO Unidade de Pesquisa Clinica em OncologiaPelotas, Brazil
Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRSPorto Alegre, Brazil
Oncoclinicas Rio de Janeiro S ARio de Janeiro, Brazil
Instituto D Or de Pesquisa e Ensino IDORRio de Janeiro, Brazil
Nucleo de Oncologia da BahiaSalvador, Brazil

+ 66 more locations — full list on the registry record.

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