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Study identifier: NCT05486572 Synced from ClinicalTrials.gov · August 02, 2026
● Recruiting

Preventing Liver Cancer Mortality Through Imaging With Ultrasound vs. MRI

Condition: Carcinoma, Hepatocellular · Cirrhosis  ·  Sponsor: VA Office of Research and Development

PhaseNA
Planned participants4700
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

The study is a randomized trial of two different screening methods for early detection of liver cancer in patients with cirrhosis of the liver. The goal of PREMIUM is to compare an abbreviated version of the diagnostic gold standard for HCC (aMRI) +AFP to the standard-of-care screening (US+AFP) in patients at high risk of developing HCC. The investigators hypothesize that HCC will be detected at earlier stages, allowing for more curative treatments and resulting in a reduction in HCC-related mortality.

This description comes directly from the study's public registry record.

Talk to the study team

George N Ioannou, MD MS  ·  (206) 277-3136  ·  George.Ioannou@va.gov

Always discuss trial participation with your own doctor first.

Locations (34)

Birmingham VA Medical Center, Birmingham, ALBirmingham, Alabama, United StatesRecruiting
Southern Arizona VA Health Care System, Tucson, AZTucson, Arizona, United StatesRecruiting
Central Arkansas Veterans Healthcare System , Little Rock, ARLittle Rock, Arkansas, United StatesRecruiting
VA Long Beach Healthcare System, Long Beach, CALong Beach, California, United StatesRecruiting
VA Palo Alto Health Care System, Palo Alto, CAPalo Alto, California, United StatesRecruiting
VA Northern California Health Care System, Mather, CASacramento, California, United StatesRecruiting
VA San Diego Healthcare System, San Diego, CASan Diego, California, United StatesRecruiting
VA Greater Los Angeles Healthcare System, West Los Angeles, CAWest Los Angeles, California, United StatesRecruiting
Rocky Mountain Regional VA Medical Center, Aurora, COAurora, Colorado, United StatesRecruiting
VA Connecticut Healthcare System West Haven Campus, West Haven, CTWest Haven, Connecticut, United StatesRecruiting
Washington DC VA Medical Center, Washington, DCWashington D.C., District of Columbia, United StatesRecruiting
Miami VA Healthcare System, Miami, FLMiami, Florida, United StatesRecruiting

+ 22 more locations — full list on the registry record.

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