Study identifier: NCT05421663 Synced from ClinicalTrials.gov · August 05, 2026
● Active Not Recruiting

A Study of JNJ-90014496 in Participants With B-Cell Non-Hodgkin Lymphoma

Condition: Lymphoma, Non-Hodgkin · Lymphoma, B-Cell · Lymphoma, Large B-Cell, Diffuse  ·  Sponsor: Janssen Research & Development, LLC

PhasePhase 1/Phase 2
Planned participants166
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a Phase 1b/2, multicenter, open-label, study of JNJ-90014496, an autologous dual targeting chimeric antigen receptor (CAR) T-cell therapy targeting both cluster of differentiation (CD) CD20 and CD19, for the treatment of adult participants with relapsed or refractory (r/r) B-Cell non-Hodgkin lymphoma (B-NHL) or frontline high-risk diffuse large B-cell lymphoma (DLBCL).

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (32)

City of HopeDuarte, California, United States
Colorado Blood Cancer InstituteDenver, Colorado, United States
University of Iowa Hospital and ClinicsIowa City, Iowa, United States
University of Kentucky Medical CenterLexington, Kentucky, United States
Rutgers Cancer Institute of New JerseyPiscataway, New Jersey, United States
Levine Cancer InstituteCharlotte, North Carolina, United States
University Hospitals Cleveland Medical CenterCleveland, Ohio, United States
University of Pittsburgh Medical CenterPittsburgh, Pennsylvania, United States
Greco Hainesworth Tennessee Oncology Centers for ResearchNashville, Tennessee, United States
Sarah Cannon Research InstituteNashville, Tennessee, United States
St. David's South Austin Medical CenterAustin, Texas, United States
MD Anderson Cancer CenterHouston, Texas, United States

+ 20 more locations — full list on the registry record.

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