Study identifier: NCT05405426 Synced from ClinicalTrials.gov · August 05, 2026
● Active Not Recruiting

Trial of Indication-Based Transfusion of Red Blood Cells in ECMO

Condition: Extracorporeal Membrane Oxygenation · Red Blood Cell Transfusion · Organ Failure, Multiple  ·  Sponsor: Boston Children's Hospital

PhaseNA
Planned participants228
Who can joinAll sexes, 0 Days to 6 Years
Healthy volunteersNo

About this study

TITRE - Trial of Indication-based Transfusion of Red Blood Cells in ECMO, is a multicenter, prospective, randomized clinical trial. The overarching goal of TITRE is to determine whether restricting red blood cell (RBC) transfusion according to an indication-based strategy for those with bleeding and/or deficit of tissue oxygen delivery, compared with transfusion based on center-specific hemoglobin or hematocrit thresholds, can reduce organ dysfunction and improve later neurodevelopment in critically ill children receiving Extracorporeal Membrane Oxygenation (ECMO) support.

This description comes directly from the study's public registry record.

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No contact information is available for this study as per the public registry record.

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Locations (22)

Phoenix Children's HospitalPhoenix, Arizona, United States
Arkansas Children's HospitalLittle Rock, Arkansas, United States
Children's Hospital Los AngelesLos Angeles, California, United States
Lucile Packard Children's HospitalPalo Alto, California, United States
Children's Hospital ColoradoAurora, Colorado, United States
Children's Healthcare of AtlantaAtlanta, Georgia, United States
Lurie Children's HospitalChicago, Illinois, United States
Riley Children's HospitalIndianapolis, Indiana, United States
Boston Children's HospitalBoston, Massachusetts, United States
University of Michigan Medical CenterAnn Arbor, Michigan, United States
Children's Hospital of MichiganDetroit, Michigan, United States
Cincinnati Children's Hospital Medical CenterCincinnati, Ohio, United States

+ 10 more locations — full list on the registry record.

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