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Study identifier: NCT05371964 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of Imetelstat in Combination With Ruxolitinib in Participants With Myelofibrosis

Condition: Myelofibrosis  ·  Sponsor: Geron Corporation

PhasePhase 1
Planned participants36
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of the study is to identify the recommended Part 2 dose (R2PD) of imetelstat sodium in combination with ruxolitinib in participants with myelofibrosis (MF) in Part 1, and to evaluate the safety and preliminary clinical activity of the R2PD of imetelstat sodium in combination with ruxolitinib in participants with MF in Part 2.

This description comes directly from the study's public registry record.

Talk to the study team

Michelle Mudge-Riley, DO  ·  650-473-7793  ·  myf1001-info@geron.com

Judy Ho  ·  650-473-7793  ·  myf1001-info@geron.com

Always discuss trial participation with your own doctor first.

Locations (8)

City of HopeDuarte, California, United StatesRecruiting
City of HopeIrvine, California, United StatesRecruiting
University of MiamiCoral Gables, Florida, United StatesRecruiting
H. Lee Moffitt Cancer Center and Research Institute, Inc.Tampa, Florida, United StatesRecruiting
Icahn School of Medicine at Mount SinaiNew York, New York, United StatesRecruiting
Texas OncologyDenison, Texas, United StatesWithdrawn
Texas OncologyTyler, Texas, United StatesWithdrawn
Fred Hutchinson Cancer CenterSeattle, Washington, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05371964