Study identifier: NCT05360446 Synced from ClinicalTrials.gov · August 05, 2026
● Active Not Recruiting

Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events

Condition: Coronary Artery Disease  ·  Sponsor: Novartis Pharmaceuticals

PhasePhase 3
Planned participants609
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

CKJX839D12303 is a research study to determine if the study treatment, called inclisiran, in comparison to placebo taken in addition to statin medication can effectively reduce the total amount of plaque formed in the heart's vessels as measured by coronary computed tomography angiography (CCTA) from baseline to month 24. This study is being conducted in eligible participants with a diagnosis of non-obstructive coronary artery disease (NOCAD), where the coronary arteries are blocked less than 50%, and with no previous cardiovascular events.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

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Locations (89)

Heart Center Research LlcHuntsville, Alabama, United States
Alaska Heart and VascularAnchorage, Alaska, United States
Cardiovascular Res FoundBeverly Hills, California, United States
UC San Diego HealthLa Jolla, California, United States
Stanford Health CareStanford, California, United States
Lundquist Inst BioMed at HarborTorrance, California, United States
Bridgeport HospitalBridgeport, Connecticut, United States
George Washington Univ Medical CtrWashington D.C., District of Columbia, United States
Inpatient Research Clinical LLCMiami Lakes, Florida, United States
NorthShore University Health SystemEvanston, Illinois, United States
Reid Physician AssociatesRichmond, Indiana, United States
Midwest Heart and Vascular SpecOverland Park, Kansas, United States

+ 77 more locations — full list on the registry record.

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