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Study identifier: NCT05337982 Synced from ClinicalTrials.gov · July 30, 2026
● Recruiting

Eccentric Muscle Training, Stimulation, and Biomarkers in SCI

Condition: Spinal Cord Injuries · Healthy  ·  Sponsor: Ohio State University

PhaseNA
Planned participants49
Who can joinAll sexes, 18 Years to 85 Years
Healthy volunteersYes

About this study

The investigators are studying a new rehabilitation treatment for individuals trying to recover walking after spinal cord injury (SCI). The investigators will test conditions in the blood and spinal fluid to determine the best time to start this new training program. This will include checking for certain features called biomarkers by testing participants' spinal fluid and blood and compare these features to individuals without SCI. These features will help investigators determine when to start the new training program, either right away or waiting for 3 months. The new training program uses walking downhill on a slight slope on a treadmill while muscles that are not working normally are stimulated to contract using low levels of electricity. Adding this stimulation will allow people to practice walking and other skills even though full muscle control has not recovered. This new program will be in addition to any other rehabilitation therapy and will not replace standard rehabilitation. The hope is to see if downhill training with muscle stimulation, when delivered at the most ideal time, will improve trunk and leg movement, walking, and overall function. This recovery of movement and function will be compared to people with SCI receiving standard rehabilitation alone. Certain regions of the brain and spinal cord will also be studied using MRI scans to determine if these are affected by the training and compare to individuals without SCI. The total length of the study for SCI…

This description comes directly from the study's public registry record.

Talk to the study team

Michele Basso, EdD, PT  ·  614-814-1404  ·  michele.basso@osumc.edu

Always discuss trial participation with your own doctor first.

Locations (2)

The Ohio State UniversityColumbus, Ohio, United StatesRecruiting
University of British ColumbiaVancouver, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT05337982