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Study identifier: NCT05271916 Synced from ClinicalTrials.gov · August 02, 2026
● Recruiting

First-line Treatment With Dacomitinib Plus Anlotinib for Patients With Advanced NSCLC With EGFR 21L858R Mutations

Condition: Non-Small Cell Lung Cancer (NSCLC)  ·  Sponsor: Shanghai Chest Hospital

PhasePhase 1/Phase 2
Planned participants140
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This is a multicenter, open label, Phase I/IIB study investigating the efficacy and safety of treatment with dacomitinib plus anlotinib as first-line therapy for patients with advanced non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) 21-L858R mutations. This study comprises two parts: 1. A dose escalation Phase I study to determine the recommended phase II dose. 2. a multi-center, open label, randomized controlled, Phase IIB study.

This description comes directly from the study's public registry record.

Talk to the study team

Bo Zhang, MD  ·  15800386291  ·  zb1063253078@163.com

Always discuss trial participation with your own doctor first.

Locations (1)

Shanghai Chest HospitalShanghai, Shanghai Municipality, ChinaRecruiting

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