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A Research Study to See How Well the New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Level in People With Type 2 Diabetes Compared to Weekly Semaglutide (COMBINE 2)
Condition: Diabetes Mellitus, Type 2 · Sponsor: Novo Nordisk A/S
About this study
This study will compare the new medicine IcoSema, which is a combination of insulin icodec and semaglutide, taken once a week, to semaglutide taken once a week in people with type 2 diabetes. The study will look at how well IcoSema controls blood sugar level in people with type 2 diabetes compared to semaglutide. Participants will either get IcoSema or semaglutide. Which treatment participants get is decided by chance. IcoSema is a new medicine that doctors cannot prescribe. Doctors can already prescribe semaglutide in many countries. Participants will get IcoSema or semaglutide, which they must inject once a week with a pen, which has a small needle, in a skin fold in the thigh, upper arm, or stomach. The study will last for about 1 year and 1 month. Participants will have 18 clinic visits, 34 phone/video calls with the study doctor, and 4 contacts with the site that can either be clinic visits or phone/video calls. At 11 clinic visits participants will have blood samples taken. At 7 clinic visits participants cannot eat or drink (except for water) for 8 hours before the visit. Women cannot take part if pregnant, breast-feeding or plan to get pregnant during the study period.
This description comes directly from the study's public registry record.
Talk to the study team
No contact information is available for this study as per the public registry record.
Always discuss trial participation with your own doctor first.
Locations (193)
| Univ of AL at Birmingham_BRM | Birmingham, Alabama, United States | — |
| Pri Med Grp dba/Gil Ctr Fam | Gilbert, Arizona, United States | — |
| Phoenician Centers for Research & Innovation PCRI | Phoenix, Arizona, United States | — |
| Clinical Research Institute of Arizona | Sun City West, Arizona, United States | — |
| John Muir Physicians Network | Concord, California, United States | — |
| Scripps Whittier Diabetes Inst | La Jolla, California, United States | — |
| Clinical Trials Research_Sacramento | Lincoln, California, United States | — |
| Downtown LA Res Ctr. Inc. | Los Angeles, California, United States | — |
| Velocity Clin Res Los Angeles | Los Angeles, California, United States | — |
| Velocity Clin Res Wstlke | Los Angeles, California, United States | — |
| Valley Clinical Trials, Inc. | Northridge, California, United States | — |
| San Diego Family Care_San Diego | San Diego, California, United States | — |
+ 181 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05259033