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Study identifier: NCT05154487 Synced from ClinicalTrials.gov · August 05, 2026
● Active Not Recruiting

A Study of Alpelisib and Fulvestrant to Treat Endometrial Cancer

Condition: Endometroid Endometrial Cancer  ·  Sponsor: GOG Foundation

PhasePhase 2
Planned participants51
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a 2 stage multi-center study designed to evaluate the efficacy of the combination of alpelisib and fulvestrant in patients with PIK3CA-mutated ER-positive endometrioid endometrial cancers by estimating the objective response rate (ORR). Treatment will continue until either unacceptable toxicity, progression of disease, or investigator/patient request for withdrawal.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

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Locations (21)

City of HopeDuarte, California, United States
Mount Sinai Medical CenterMiami Beach, Florida, United States
AdventHealth Gynecologic OncologyOrlando, Florida, United States
Tampa General HospitalTampa, Florida, United States
Moffit Cancer Center at International PlazaTampa, Florida, United States
Moffitt Cancer CenterTampa, Florida, United States
Moffit Cancer Center at Wesley ChapelWesley Chapel, Florida, United States
Endeavor HealthEvanston, Illinois, United States
Endeavor Health Clinical Operations, Glenbrook HospitalGlenview, Illinois, United States
Endeavor Health Clinical Operations, Highland Park HospitalHighland Park, Illinois, United States
Ascension St. VincentIndianapolis, Indiana, United States
Norton Cancer InstituteLouisville, Kentucky, United States

+ 9 more locations — full list on the registry record.

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