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Study identifier: NCT05145413 Synced from ClinicalTrials.gov · August 04, 2026
● Completed

A Study to Assess Efficacy and Safety of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of Schizophrenia

Condition: Schizophrenia  ·  Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company

PhasePhase 3
Planned participants396
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

This is a Phase 3, 6-week, randomized, double-blind, placebo-controlled, multicenter, outpatient study in subjects with schizophrenia with an inadequate response to their current atypical antipsychotic treatment. The primary objective of the study is to assess the efficacy of adjunctive KarXT (a fixed dose combination of xanomeline and trospium chloride twice daily \[BID\]) versus placebo in the treatment of subjects with inadequately controlled symptoms of schizophrenia as measured by the Positive and Negative Syndrome Scale (PANSS) Total Score.

This description comes directly from the study's public registry record.

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No contact information is available for this study as per the public registry record.

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Locations (166)

IMA Clinical ResearchPhoenix, Arizona, United States
Local Institution - 147Phoenix, Arizona, United States
Pillar Clinical Research, LLCLittle Rock, Arkansas, United States
Woodland International Research Group, LLCLittle Rock, Arkansas, United States
Advanced Research Center, Inc.Anaheim, California, United States
CITrials - BellflowerBellflower, California, United States
Synexus Clinical Research US, Inc.Cerritos, California, United States
Clinical Innovations Inc.Costa Mesa, California, United States
Proscience Research GroupCulver City, California, United States
CenExel Collaborative Neuroscience ResearchGarden Grove, California, United States
Omega Clinical TrialsLa Habra, California, United States
Sunwise Clinical Research, LLC.Lafayette, California, United States

+ 154 more locations — full list on the registry record.

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