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A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer
Condition: HER2 Positive Breast Cancer · Sponsor: Seagen, a wholly owned subsidiary of Pfizer
About this study
This study is being done to see if tucatinib works better than placebo when given with other drugs to treat participants with HER2-positive breast cancer. A placebo is a pill that looks the same as tucatinib but has no medicine in it. This study will also test what side effects happen when participants take this combination of drugs. A side effect is anything a drug does to the body besides treating your disease. Participants will have cancer that has spread in the body near where it started (locally advanced) and cannot be removed (unresectable) or has spread through the body (metastatic). In this study, all participants will get either tucatinib or placebo. Participants will be assigned randomly to a group. This is a blinded study, so patients and their doctors will not know which group a participant is in. All participants will also get trastuzumab and pertuzumab. These are 2 drugs used to treat this type of cancer.
This description comes directly from the study's public registry record.
Talk to the study team
No contact information is available for this study as per the public registry record.
Always discuss trial participation with your own doctor first.
Locations (307)
| Mayo Clinic Hospital | Phoenix, Arizona, United States | — |
| Mayo Clinic | Scottsdale, Arizona, United States | — |
| Central Arkansas Radiation Therapy Institute Inc d.b.a CARTI | Little Rock, Arkansas, United States | — |
| UCLA Hematology/Oncology - Beverly Hills | Beverly Hills, California, United States | — |
| UCLA Hematology/Oncology - Burbank | Burbank, California, United States | — |
| UCSD Medical Center - Encinitas | Encinitas, California, United States | — |
| Sulpizio Cardiovascular Center at UC San Diego Health | La Jolla, California, United States | — |
| UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Pavilion) | La Jolla, California, United States | — |
| UCSD Koman Family Outpatient Pavilion | La Jolla, California, United States | — |
| UCSD Perlman Medical Offices | La Jolla, California, United States | — |
| UC San Diego Moores Cancer Center | La Jolla, California, United States | — |
| UCLA Hematology/Oncology - Laguna Hills | Laguna Hills, California, United States | — |
+ 295 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05132582