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Study identifier: NCT05100862 Synced from ClinicalTrials.gov · August 05, 2026
● Active Not Recruiting

A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma

Condition: Relapsed/Refractory Follicular Lymphoma · Marginal Zone Lymphoma  ·  Sponsor: BeOne Medicines

PhasePhase 3
Planned participants799
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of the study is to compare the efficacy of zanubrutinib plus obinutuzumab versus lenalidomide plus rituximab (R\^2) in participants with relapsed/refractory (R/R) follicular lymphoma (FL), as measured by progression-free survival as determined by an independent review committee in accordance with the 2014 modification of the International Working Group on non-Hodgkin lymphoma (NHL) Criteria based on n positron emission tomography and computed tomography (PET/CT), and to compare the efficacy of zanubrutinib plus rituximab versus R\^2 in participants with R/R marginal zone lymphoma (MZL), as measured by progression free survival (PFS) assessed by IRC in accordance with CT-based Lugano 2014 Criteria.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (270)

Ucsf Fresno University of California San Francisco FresnoFresno, California, United States
Kaiser Permanente Southern CaliforniaIrvine, California, United States
Cancer and Blood Specialty ClinicLos Alamitos, California, United States
Los Angeles Cancer NetworkLos Angeles, California, United States
Valkyrie Clinical TrialsLos Angeles, California, United States
UCLA HematologyoncologyLos Angeles, California, United States
Scripps HealthSan Diego, California, United States
Sharp Healthcare Sharp Memorial HospitalSan Diego, California, United States
Baptist Md Anderson Cancer CenterJacksonville, Florida, United States
Ascension Sacred HeartPensacola, Florida, United States
Northwest Georgia Oncology Centers MariettaMarietta, Georgia, United States
Cancer Care Specialists of IllinoisDecatur, Illinois, United States

+ 258 more locations — full list on the registry record.

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