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Study identifier: NCT05096481 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

Condition: High Grade Glioma · Diffuse Intrinsic Pontine Glioma · Recurrent Medulloblastoma  ·  Sponsor: Nationwide Children's Hospital

PhasePhase 2
Planned participants120
Who can joinAll sexes, 3 Years to 39 Years
Healthy volunteersNo

About this study

This study will address the question of whether targeting CMV antigens with PEP-CMV can serve as a novel immunotherapeutic approach in pediatric patients with newly-diagnosed high-grade glioma (HGG) or diffuse intrinsic pontine glioma (DIPG) as well as recurrent medulloblastoma (MB). PEP-CMV is a vaccine mixture of a peptide referred to as Component A. Component A is a synthetic long peptide (SLP) of 26 amino acid residues from human pp65. The SLPs encode multiple potential class I, class II, and antibody epitopes across several haplotypes. Component A will be administered as a stable water:oil emulsion in Montanide ISA 51. Funding Source - FDA OOPD

This description comes directly from the study's public registry record.

Talk to the study team

Kelsey H Troyer, PhD  ·  6147223284  ·  kelsey.troyer@nationwidechildrens.org

Always discuss trial participation with your own doctor first.

Locations (13)

Children's Hospital ColoradoAurora, Colorado, United StatesRecruiting
Children's National Medical CenterWashington D.C., District of Columbia, United StatesRecruiting
Nicklaus Children's HospitalMiami, Florida, United StatesRecruiting
Ann & Robert H. Lurie Children's Hospital of ChicagoChicago, Illinois, United StatesNot Yet Recruiting
Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesNot Yet Recruiting
C.S. Mott Children's HospitalAnn Arbor, Michigan, United StatesRecruiting
St. Louis Children's HospitalSt Louis, Missouri, United StatesRecruiting
Duke Cancer CenterDurham, North Carolina, United StatesRecruiting
Cincinnati Children's Hospital Medical CenterCincinnati, Ohio, United StatesRecruiting
Nationwide Children's HospitalColumbus, Ohio, United StatesRecruiting
Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania, United StatesNot Yet Recruiting
Texas Children's HospitalHouston, Texas, United StatesRecruiting

+ 1 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05096481