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Study identifier: NCT05070858 Synced from ClinicalTrials.gov · August 03, 2026
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A Study to Test How Safe Pozelimab and Cemdisiran Combination Therapy and Cemdisiran Alone Are and How Well They Work in Adult Patients With Generalized Myasthenia Gravis

Condition: Generalized Myasthenia Gravis  ·  Sponsor: Regeneron Pharmaceuticals

PhasePhase 3
Planned participants288
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study is researching the experimental drugs called pozelimab and cemdisiran, and cemdisiran monotherapy. The study is focused on patients with generalized Myasthenia Gravis (gMG). Myasthenia gravis is a disease that causes weakness and fatigue in muscles in the body because the nerves and muscles are not communicating properly. The aim of the study is to see how effective pozelimab and cemdisiran are when used in combination and when pozelimab and cemdisiran are used alone for patients with gMG. The study is looking at several other research questions, including: * What side effects may happen from taking the study drugs * How the study drugs work inside the body * How much of the study drugs are in the blood at different times * Whether the body makes antibodies against pozelimab and cemdisiran (which could make the drugs less effective or could lead to side effects)

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (116)

HonorHealth Neurology 2018Scottsdale, Arizona, United States
University of California IrvineIrvine, California, United States
University of Southern CaliforniaLos Angeles, California, United States
Colorado Springs Neurological AssociatesColorado Springs, Colorado, United States
SFM Clinical Research, LLCBoca Raton, Florida, United States
Diverse Clinical ResearchMiami, Florida, United States
Aqualane Clinical ResearchNaples, Florida, United States
Neurological Services of OrlandoOrlando, Florida, United States
Medsol Clinical Research Center IncPort Charlotte, Florida, United States
University of South Florida Morsani Center for Advanced HealthcareTampa, Florida, United States
NorthShore University Health SystemGlenview, Illinois, United States
St. Elizabeth's HospitalO'Fallon, Illinois, United States

+ 104 more locations — full list on the registry record.

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