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Study identifier: NCT05058404 Synced from ClinicalTrials.gov · August 03, 2026
● Active Not Recruiting

Shortened vs Standard Chemotherapy Combined With Immunotherapy for the Initial Treatment of Patients With High Tumor Burden Follicular Lymphoma

Condition: Follicular Lymphoma  ·  Sponsor: Fondazione Italiana Linfomi - ETS

PhasePhase 3
Planned participants605
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

FIL\_FOLL19 is an open-label, multicenter, randomized phase III trial. The sponsor of this clinical trial is Fondazione Italiana Linfomi (FIL). The Primary Objective of the study is to demonstrate that, in patients with newly diagnosed, advanced stage Follicular Lymphoma (FL) with high tumor burden according to the Groupe d'Etude des Lymphomes Folliculaires (GELF) criteria, a treatment strategy that reduces the number of chemotherapy cycles in case of early response to immunochemotherapy is not inferior compared to standard therapy at full dose in terms of Progression-Free Survival (PFS).

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (54)

IRCCS Istituto Romagnolo per lo studio dei Tumori "Dino Amadori" - IRST S.R.L. - EmatologiaMeldola, Forlì - Cesena, Italy
U.O.C. Ematologia Ospedale Civile di LegnanoLegnano, Milano, Italy
Nuovo Ospedale Civile di Sassuolo - Day Hospital OncologicoSassuolo, Modena, Italy
ASST MONZA Ospedale S. Gerardo - EmatologiaMonza, Monza E Brianza, Italy
IRCCS Centro di Riferimento Oncologico di Aviano - Divisione di Oncologia e dei Tumori immuto-correlatiAviano, Pordenone, Italy
Presidio ospedaliero "A. TORTORA" - U.O. Onco-ematologiaPagani, Salerno, Italy
Fondazione del Piemonte per l'Oncologia - IRCCS - EmatologiaCandiolo, Torino, Italy
Ospedale di Castelfranco Veneto - EmatologiaCastelfranco Veneto, Treviso, Italy
ASST Valle Olona - Ospedale di Circolo di Busto Arsizio - S.C. EmatologiaBusto Arsizio, Varese, Italy
USLL13 - Dipartimento di Scienze Mediche UOC di Oncologia ed Ematologia OncologicaMirano, Venezia, Italy
A.O. SS. Antonio e Biagio e Cesare Arrigo - S.C. EmatologiaAlessandria, Italy
AOU Ospedali Riuniti - Clinica di EmatologiaAncona, Italy

+ 42 more locations — full list on the registry record.

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