Guiding Instillation in Non Muscle-invasive Bladder Cancer Based on Drug Screens in Patient Derived Organoids
Condition: Bladder Cancer · Non-muscle Invasive · Sponsor: Roland Seiler-Blarer
About this study
From patients with intermediate risk non-muscle invasive bladder cancer tumor (NMIBC) specimens will be harvested during transurethral resection. Fresh specimens will be cultured as patient derived organoids (PDO). After approx. 10 days, PDO are exposed to different drugs that are used as intravesical instillation agents in these patients (epirubicin, mitomycin, gemcitabine, docetaxel). After 2 days of exposure, PDO viability will be measured. The drug with the highest antitumor effect on PDO will be applied as weekly intravesical instillations 6 times. Thereafter, patients are followed according to the standard of care.
This description comes directly from the study's public registry record.
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No contact information is available for this study as per the public registry record.
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Locations (1)
| Spitalzentrum Biel/Bienne | Biel, Switzerland | — |
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Source record: clinicaltrials.gov/study/NCT05024734