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Study identifier: NCT05021835 Synced from ClinicalTrials.gov · August 02, 2026
● Completed

ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation

Condition: Cardiovascular Risk · Chronic Kidney Disease · Inflammation  ·  Sponsor: Novo Nordisk A/S

PhasePhase 3
Planned participants6385
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study is conducted to see if ziltivekimab reduces the risk of having cardiovascular events (for example heart attack and stroke) in people with cardiovascular disease, chronic kidney disease and inflammation. Participants will either get ziltivekimab (active medicine) or placebo (a dummy medicine which has no effect on the body). This is known as the study medicine. Which treatment participants get is decided by chance. Participants chance of getting ziltivekimab or placebo is the same. Ziltivekimab is not yet approved in any country or region in the world. It is a new medicine doctors cannot prescribe. Participants will get the study medicine in a pre filled syringe. Participants will need to use the pre filled syringe to inject the study medicine into a skinfold once-monthly. The study is expected to last for up to 4 years. Participants will have up to 20 clinic visits. Participants will have blood and urine samples taken at most of the clinic visits. Participants will have their heart examined using sound waves (echocardiography) and electrodes (electrocardiogram). Women cannot take part if pregnant, breast-feeding or planning to get pregnant during the study period.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (1071)

Uni of Alabama at BirminghamBirmingham, Alabama, United States
Chambliss Clinical Trials LLCMontgomery, Alabama, United States
Lenzmeier Fam Med CCT ResearchGlendale, Arizona, United States
Aventiv Research Inc.Mesa, Arizona, United States
Univ of Arkansas Med SciencesLittle Rock, Arkansas, United States
Unity Health-Searcy Medical CenterSearcy, Arkansas, United States
National Heart Institute CalBeverly Hills, California, United States
California Inst Of Renal ResChula Vista, California, United States
California Institute of Renal Research #10Chula Vista, California, United States
Valley Clinical TrialsCovina, California, United States
Valiance Clinical ResearchHuntington Park, California, United States
Scripps Wht Diab Inst La JollaLa Jolla, California, United States

+ 1059 more locations — full list on the registry record.

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