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A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure
Condition: Carcinoma, Non-Small-Cell Lung · Sponsor: Janssen Research & Development, LLC
About this study
The purpose of this study is to assess the efficacy of adding lazertinib to amivantamab, carboplatin, and pemetrexed (LACP/ACP-L dosing strategies) and amivantamab, carboplatin and pemetrexed (ACP) compared with carboplatin and pemetrexed (CP) in participants with locally advanced or metastatic epidermal growth factor receptor (EGFR) Exon 19del or Exon 21 L858R substitution non-small cell lung cancer (NSCLC) after osimertinib failure. The purpose of the extension cohort is to further describe the safety and efficacy for the ACP-L dosing schedule versus ACP with additional data. After completion of the primary analysis, the study may eventually transition to an open-label extension (OLE) or long-term extension (LTE) phase during which participants will have the option to continue their assigned treatment.
This description comes directly from the study's public registry record.
Talk to the study team
No contact information is available for this study as per the public registry record.
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Locations (249)
| Southern Cancer Center, PC | Mobile, Alabama, United States | — |
| Arizona Oncology Associates | Tucson, Arizona, United States | — |
| City of Hope | Duarte, California, United States | — |
| Cedars Sinai Medical Center | Los Angeles, California, United States | — |
| University of California Irvine | Orange, California, United States | — |
| Rocky Mountain Cancer Centers | Colorado Springs, Colorado, United States | — |
| Holy Cross Hospital - Michael and Dianne Bienes Comprehensive Cancer Center | Fort Lauderdale, Florida, United States | — |
| University Cancer And Blood Center LLC | Athens, Georgia, United States | — |
| University of Mississippi Medical Center | Jackson, Mississippi, United States | — |
| Nebraska Cancer Specialists | Grand Island, Nebraska, United States | — |
| Astera Cancer Care | East Brunswick, New Jersey, United States | — |
| TriHealth Network | Cincinnati, Ohio, United States | — |
+ 237 more locations — full list on the registry record.
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