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A Study to Test BI 765179 Alone and in Combination With Ezabenlimab in Patients With Advanced Cancer (Solid Tumors) and BI 765179 in Combination With Pembrolizumab in Patients With Advanced Head and Neck Cancer
Condition: Neoplasms · Sponsor: Boehringer Ingelheim
About this study
This study is open to adults with advanced cancer (solid tumors) and people with advanced head and neck cancer. The study has 2 parts. The purpose of Part 1 of this study is to find the highest dose of a medicine called BI 765179 that people with solid tumors can tolerate when taken alone or together with a medicine called ezabenlimab. The goal of Part 2 is to find out whether BI 765179 in combination with a medicine called pembrolizumab helps people with advanced head and neck cancer. In Part 1, each participant is put into 1 of 2 groups. Participants get BI 765179 alone or in combination with ezabenlimab as infusion into a vein every 3 weeks. In Part 2, participants are also divided into 2 groups. 1 group gets a low dose of BI 765179 in combination with pembrolizumab and the other group gets a high dose of BI 765179 in combination with pembrolizumab. Participants receive the study treatment as infusions into a vein. BI 765179, ezabenlimab, and pembrolizumab are antibodies that may help the immune system fight cancer. In this study, BI 765179 is given to people for the first time. Participants can stay in the study up to 2 years if they benefit from treatment and can tolerate it. The doctors regularly check the participants' health and note any health problems that could have been caused by the study treatment.
This description comes directly from the study's public registry record.
Talk to the study team
No contact information is available for this study as per the public registry record.
Always discuss trial participation with your own doctor first.
Locations (48)
| University of Arizona | Tucson, Arizona, United States | — |
| Beverly Hills Cancer Center | Beverly Hills, California, United States | — |
| The University of North Carolina at Chapel Hill | Chapel Hill, North Carolina, United States | — |
| Avera Cancer Institute | Sioux Falls, South Dakota, United States | — |
| NEXT Oncology-San Antonio-65273 | San Antonio, Texas, United States | — |
| Border Cancer Hospital | Albury, New South Wales, Australia | — |
| Kinghorn Cancer Centre | Darlinghurst, New South Wales, Australia | — |
| Townsville Hospital | Douglas, Queensland, Australia | — |
| Austin Hospital | Heidelberg, Victoria, Australia | — |
| Cliniques Universitaires Saint-Luc | Brussels, Belgium | — |
| Universitair Ziekenhuis Antwerpen | Edegem, Belgium | — |
| AZ Groeninge | Kortrijk, Belgium | — |
+ 36 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04958239