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Beamion LUNG-1: A Study to Test Different Doses of Zongertinib in People With Different Types of Advanced Cancer (Solid Tumours With Changes in the HER2 Gene)
Condition: Neoplasm Metastasis · Non-Small Cell Lung Cancer · Sponsor: Boehringer Ingelheim
About this study
The study has 2 parts. The first part is open to adults with different types of advanced cancer (solid tumours with changes in the HER2 gene) for whom previous treatment was not successful. The second part is open to people with non-small cell lung cancer with a specific mutation in the HER2 gene. The purpose of the first study part is to find the highest dose of a medicine called zongertinib the participants can tolerate. Once this dose is found, it will be used in the second study part to test whether zongertinib can make tumours shrink. In this study, zongertinib is given to people for the first time. Participants take zongertinib as tablets once a day or twice a day. The participants are in the study for as long as they benefit from and can tolerate treatment. Study doctors regularly check the participants' health and monitor the tumours. The doctors also take note of any unwanted effects that could have been caused by zongertinib.
This description comes directly from the study's public registry record.
Talk to the study team
No contact information is available for this study as per the public registry record.
Always discuss trial participation with your own doctor first.
Locations (85)
| University of Alabama at Birmingham | Birmingham, Alabama, United States | — |
| Precision NextGen Oncology | Beverly Hills, California, United States | — |
| City of Hope-Duarte-56419 | Duarte, California, United States | — |
| City of Hope - Seacliff | Huntington Beach, California, United States | — |
| City of Hope-Irvine-69674 | Irvine, California, United States | — |
| Valkyrie Clinical Trials | Los Angeles, California, United States | — |
| University of California Irvine | Orange, California, United States | — |
| University of California Davis | Sacramento, California, United States | — |
| Georgetown University | Washington D.C., District of Columbia, United States | — |
| Holy Cross Hospital-Fort Lauderdale-57892 | Fort Lauderdale, Florida, United States | — |
| Winship Cancer Institute | Atlanta, Georgia, United States | — |
| Hawaii Cancer Care - Honolulu | Honolulu, Hawaii, United States | — |
+ 73 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04886804