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Venetoclax, MLN9708 (Ixazomib Citrate) and Dexamethasone for the Treatment of Relapsed or Refractory Light Chain Amyloidosis
Condition: Recurrent AL Amyloidosis · Refractory AL Amyloidosis · Sponsor: National Cancer Institute (NCI)
About this study
This phase I/Ia trial finds the best dose and side effects of venetoclax given in combination with ixazomib citrate and dexamethasone in treating patients with light chain amyloidosis that has come back (relapsed) or does not respond to treatment (refractory) and who have an abnormal genetic change \[translocation t(11;14)\]. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Ixazomib citrate is in a class of medications called proteasome inhibitors. It works by helping to kill cancer cells. Anti-inflammatory drugs such as dexamethasone reduce inflammation by lowering the body's immune response and are used with other drugs in the treatment of some types of cancer. Combination therapy with venetoclax, ixazomib citrate and dexamethasone may be effective in treatment of relapsed or refractory light chain amyloidosis.
This description comes directly from the study's public registry record.
Talk to the study team
No contact information is available for this study as per the public registry record.
Always discuss trial participation with your own doctor first.
Locations (16)
| City of Hope Comprehensive Cancer Center | Duarte, California, United States | — |
| University of California Davis Comprehensive Cancer Center | Sacramento, California, United States | — |
| Emory University Hospital/Winship Cancer Institute | Atlanta, Georgia, United States | — |
| Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore, Maryland, United States | — |
| Boston Medical Center | Boston, Massachusetts, United States | — |
| Dana-Farber Cancer Institute | Boston, Massachusetts, United States | — |
| Montefiore Medical Center-Einstein Campus | The Bronx, New York, United States | — |
| Montefiore Medical Center-Weiler Hospital | The Bronx, New York, United States | — |
| Montefiore Medical Center - Moses Campus | The Bronx, New York, United States | — |
| UNC Lineberger Comprehensive Cancer Center | Chapel Hill, North Carolina, United States | — |
| Ohio State University Comprehensive Cancer Center | Columbus, Ohio, United States | — |
| UPMC Hillman Cancer Center | Pittsburgh, Pennsylvania, United States | — |
+ 4 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04847453