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Study identifier: NCT04795531 Synced from ClinicalTrials.gov · August 03, 2026
● Completed

A Research Study to Compare Two Types of Insulin, a New Insulin, Insulin Icodec and an Available Insulin, Insulin Degludec, in People With Type 2 Diabetes Who Have Not Used Insulin Before (ONWARDS 3)

Condition: Diabetes Mellitus, Type 2  ·  Sponsor: Novo Nordisk A/S

PhasePhase 3
Planned participants588
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study compares insulin icodec (a new insulin taken once a week) to insulin degludec (an insulin taken once daily which is already available on the market) in people with type 2 diabetes. The study will look at how well insulin icodec taken weekly controls blood sugar compared to insulin degludec taken daily. Participants will get their study medicine in an injection pen. Participants will get a pen for weekly injection and one for daily injection. One will be icodec or degludec and the other will be dummy medicine. The treatment participants get is decided by chance. Participants and the study staff will not know which active medicine they get. The insulin is injected with a needle in a skin fold in the thigh. The study could last for about 8 months. Participants will have 13 clinic visits and 17 phone calls with the study doctor. At 8 clinic visits participants will have blood samples taken. At 4 clinic visits participants cannot eat or drink (except for water) for 8 hours before the visit. Women cannot take part if pregnant, breast-feeding or plan to become pregnant during the study period.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (190)

Univ of Alabama BirminghamBirmingham, Alabama, United States
Lakeview Clinical Research, LLCGuntersville, Alabama, United States
Lynn Institute of the OzarksLittle Rock, Arkansas, United States
Anaheim Clinical Trials, LLCAnaheim, California, United States
Advanced Clinical Research/Rancho Paseo Medical GroupBanning, California, United States
American Clinical TrialsBuena Park, California, United States
Med Center Medical ClinicCarmichael, California, United States
Headlands Research California, LLCEscondido, California, United States
Valley ResearchFresno, California, United States
Scripps Whittier Diabetes InstLa Jolla, California, United States
First Valley Medical GroupLancaster, California, United States
Clinical Trials Research_SacramentoLincoln, California, United States

+ 178 more locations — full list on the registry record.

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