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Study identifier: NCT04777396 Synced from ClinicalTrials.gov · August 03, 2026
● Completed

A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE)

Condition: Early Alzheimer's Disease  ·  Sponsor: Novo Nordisk A/S

PhasePhase 3
Planned participants1840
Who can joinAll sexes, 55 Years to 85 Years
Healthy volunteersNo

About this study

This study is done to find out whether the medicine, semaglutide, has a positive effect on early Alzheimer's disease. Participants will either get semaglutide or placebo (a "dummy" medicine which does not contain any study medicine) - which treatment participants get is decided by an equal chance. The study will last for up to 173 weeks (about 3 years and 4 months). Participants will have 17 clinic visits and 1 phone call with the study doctor. The study includes various tests and scans. At 10 of the clinic visits participants will have blood samples taken. Participants must have a study partner, who is willing to take part in the study. Women cannot take part if pregnant, breastfeeding or plan to become pregnant during the study period. A cerebrospinal fluid (CSF) sub-study will be performed as a part of the study. The sub-study will be performed on a selection of sites based on their experience with CSF sampling and willingness to participate in this sub-study. The endpoints related to this sub-study are exploratory only.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (447)

Banner Alzheimer's InstitutePhoenix, Arizona, United States
Imaging EndpointsScottsdale, Arizona, United States
Banner Sun Health Research InstituteSun City, Arizona, United States
Tucson Neuroscience ResearchTucson, Arizona, United States
Advanced Research Center, Inc.Anaheim, California, United States
Fullerton Neurology and Headache CenterFullerton, California, United States
Pacific Research NetworkLemon Grove, California, United States
Torrance Clin Res Inst, Inc.Lomita, California, United States
ASCLEPES Research Centers,Long Beach, California, United States
Cedars-Sinai Medical CenterLos Angeles, California, United States
UCLA_Los AngelesLos Angeles, California, United States
Wr-Pri, LlcNewport Beach, California, United States

+ 435 more locations — full list on the registry record.

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