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Study identifier: NCT04723004 Synced from ClinicalTrials.gov · August 03, 2026
● Completed

Evaluate the Safety and Efficacy of Toripalimab Combined With Bevacizumab Versus Sorafenib Therapy for HCC

Condition: Advanced Hepatocellular Carcinoma (HCC)  ·  Sponsor: Shanghai Junshi Bioscience Co., Ltd.

PhasePhase 3
Planned participants326
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This is a prospective, randomized, open-label, parallel-group, active controlled, multi-center phase III registration clinical study to observe, compare and evaluate the efficacy and safety of Toripalimab (hereafter referred to as JS001) combined with Bevacizumab versus Sorafenib as the first-line therapy for advanced HCC This study will enroll the patients with locally advanced or metastatic hepatocellular carcinoma who could not be radically cured and not receive any prior systemic therapy. The study will use PFS and OS as the co-primary endpoints, with approximately 280 patients planned to be enrolled.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

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Locations (56)

The First Affiliated Hospital of Bengbu Medical collegeBengbu, Anhui, China
Anhui Cancer HospitalHefei, Anhui, China
Anhui Provincial HospitalHefei, Anhui, China
The Second Hospital of Anhui Medical UniversityHefei, Anhui, China
Beijing Cancer HospitalBeijing, Beijing Municipality, China
China PLA General HospitalBeijing, Beijing Municipality, China
Peking Union Medical College HospitalBeijing, Beijing Municipality, China
Army Medical Center of PLAChongqing, Chongqing Municipality, China
The First Affiliated Hospital of Chongqing Medical UniversityChongqing, Chongqing Municipality, China
The Southwest Hospital Of AMUChongqing, Chongqing Municipality, China
The Frist Hospital of Lanzhou UniversityLanzhou, Gansu, China
Gansu Wuwei Tumor HospitalWuwei, Gansu, China

+ 44 more locations — full list on the registry record.

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