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A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Ocrelizumab in Adult Participants With Primary Progressive Multiple Sclerosis
Condition: Multiple Sclerosis, Primary Progressive · Sponsor: Hoffmann-La Roche
About this study
A study to evaluate the efficacy and safety of fenebrutinib on disability progression in adult participants with Primary Progressive Multiple Sclerosis (PPMS). All eligible participants will be randomized 1:1 to either daily oral fenebrutinib (and placebo) or intravenous (IV) ocrelizumab (and placebo) in a blinded fashion through an interactive voice or web-based response system (IxRS). 985 participants were enrolled and recruited globally. Participants who discontinue study medication early or discontinue from the study will not be replaced. The Open-Label Extension (OLE) phase is contingent on a positive benefit-risk result in the Primary Analysis of the study.
This description comes directly from the study's public registry record.
Talk to the study team
No contact information is available for this study as per the public registry record.
Always discuss trial participation with your own doctor first.
Locations (190)
| Alabama Neurology Associates | Homewood, Alabama, United States | — |
| Sutter East Bay Medical Foundation | Berkeley, California, United States | — |
| Fullerton Neurology and Headache Center | Fullerton, California, United States | — |
| Palo Alto Medical Foundation Research Center | Sunnyvale, California, United States | — |
| University of Colorado Denver | Aurora, Colorado, United States | — |
| Yale University School Of Medicine | Fairfield, Connecticut, United States | — |
| Georgetown University Medical Center | Washington D.C., District of Columbia, United States | — |
| Neurology Associates PA | Maitland, Florida, United States | — |
| Neurological Services of Orlando | Orlando, Florida, United States | — |
| University of South Florida | Tampa, Florida, United States | — |
| Josephson Wallack Munshower Neurology PC | Indianapolis, Indiana, United States | — |
| University of Kansas Medical Center | Kansas City, Kansas, United States | — |
+ 178 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04544449