Testing a New Immune Cell Therapy, GD2-Targeted Modified T-cells (GD2CART), in Children, Adolescents, and Young Adults With Relapsed/Refractory Osteosarcoma and Neuroblastoma, GD2-CAR PERSIST Trial
Condition: Recurrent Childhood Neuroblastoma · Recurrent Childhood Osteosarcoma · Recurrent Neuroblastoma · Sponsor: National Cancer Institute (NCI)
About this study
This phase I trial investigates the side effects and determines the best dose of an immune cell therapy called GD2CART, as well as how well it works in treating patients with osteosarcoma or neuroblastoma that has come back (relapsed) or does not respond to treatment (refractory). T cells are infection fighting blood cells that can kill tumor cells. The T cells given in this trial will come from the patient and will have a new gene put in them that makes them able to recognize GD2, a protein on the surface of tumor cells. These GD2-specific T cells may help the body's immune system identify and kill GD2 positive tumor cells.
This description comes directly from the study's public registry record.
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No contact information is available for this study as per the public registry record.
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Locations (6)
| Children's Hospital Los Angeles | Los Angeles, California, United States | — |
| Lucile Packard Children's Hospital Stanford University | Palo Alto, California, United States | — |
| Children's Hospital Colorado | Aurora, Colorado, United States | — |
| National Institutes of Health Clinical Center | Bethesda, Maryland, United States | — |
| Children's Hospital of Philadelphia | Philadelphia, Pennsylvania, United States | — |
| University of Wisconsin Carbone Cancer Center - University Hospital | Madison, Wisconsin, United States | — |
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Source record: clinicaltrials.gov/study/NCT04539366