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Study identifier: NCT04497844 Synced from ClinicalTrials.gov · August 02, 2026
● Active Not Recruiting

A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC)

Condition: Metastatic Castration-sensitive Prostate Cancer  ·  Sponsor: Janssen Research & Development, LLC

PhasePhase 3
Planned participants696
Who can joinMale, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of the study is to determine if the combination of niraparib with Abiraterone Acetate (AA) plus prednisone compared with AA plus prednisone in participants with deleterious germline or somatic Homologous Recombination Repair (HRR) gene-mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC) provides superior efficacy in improving radiographic progression-free survival (rPFS).

This description comes directly from the study's public registry record.

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No contact information is available for this study as per the public registry record.

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Locations (387)

Urology Centers Of AlabamaHomewood, Alabama, United States
Mayo Clinic ArizonaPhoenix, Arizona, United States
Urological Associates of Southern Arizona, P.C.Tucson, Arizona, United States
Greater Los Angeles VA Healthcare SystemLos Angeles, California, United States
University of California Irvine Medical Center Chao Family Comprehensive Cancer CenterOrange, California, United States
San Bernardino Urological AssociatesSan Bernardino, California, United States
University of San Francisco CaliforniaSan Francisco, California, United States
Rocky Mountain Cancer CentersColorado Springs, Colorado, United States
AdventHealth Medical Group Urology of DenverDenver, Colorado, United States
Colorado Clinical ResearchLakewood, Colorado, United States
Eastern Connecticut Hematology & Oncology Assoc.Norwich, Connecticut, United States
Advanced Urology InstituteDaytona Beach, Florida, United States

+ 375 more locations — full list on the registry record.

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