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Study identifier: NCT04486378 Synced from ClinicalTrials.gov · August 04, 2026
● Active Not Recruiting

A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer

Condition: Colorectal Cancer Stage II · Colorectal Cancer Stage III  ·  Sponsor: BioNTech SE

PhasePhase 2
Planned participants327
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a multi-site, open-label, Phase II, randomized, trial to compare the efficacy of RO7198457 versus watchful waiting in patients with circulating tumor DNA (ctDNA) positive, surgically resected Stage II/III rectal cancer, or Stage II (high risk)/Stage III colon cancer.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

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Locations (86)

Marin Cancer CareGreenbrae, California, United States
Rocky Mountain Cancer Centers - Denver MidtwonDenver, Colorado, United States
Indiana University Melvin and Bren Simon Comprehensive CancerIndianapolis, Indiana, United States
Allina HealthMinneapolis, Minnesota, United States
Oncology Hematology Care Clinical TrialsCincinnati, Ohio, United States
Rhode Island HospitalProvidence, Rhode Island, United States
Sarah Cannon (Tennessee Oncology - Nashville)Nashville, Tennessee, United States
Texas Oncology, P.A. - AustinAustin, Texas, United States
Texas Oncology-Baylor Charles A. Sammons Cancer CenterDallas, Texas, United States
The University of Texas MD Anderson Cancer CenterHouston, Texas, United States
Texas Oncology-San Antonio Medical CenterSan Antonio, Texas, United States
Texas Oncology - Northeast TexasTyler, Texas, United States

+ 74 more locations — full list on the registry record.

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