Condition: Treatment Resistant Depression · Major Depressive Episode · Major Depression · Sponsor: Mark Niciu
The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD) and Obsessive-Compulsive Disorder (OCD). These treatments include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), racemic ketamine infusion and intranasal esketamine insufflation. The investigators will obtain various indicators, or biomarkers, of a depressed individuals' state before, during, and/or after these treatments. Such biomarkers include neurobehavioral testing, neuroimaging, electroencephalography, cognitive testing, vocal recordings, epi/genetic testing, and autonomic nervous system measures (i.e. "fight-or-flight" response). The results obtained from this study may provide novel antidepressant treatment response biomarkers, with the future goal of targeting a given treatment to an individual patient ("personalized medicine").
This description comes directly from the study's public registry record.
Karin Nielsen, MS · 319-384-6521 · karin-nielsen@uiowa.edu
Emerson Buse, BA · 319-353-8536 · emerson-buse@uiowa.edu
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| University of Iowa Health Care | Iowa City, Iowa, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04480918