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Study identifier: NCT04435626 Synced from ClinicalTrials.gov · August 02, 2026
● Completed

Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40%

Condition: Heart Failure  ·  Sponsor: Bayer

PhasePhase 3
Planned participants6016
Who can joinAll sexes, 40 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the effect of finerenone compared to placebo (a tablet without active substance) in the reduction of cardiovascular death (generally meaning death due to disease of the heart or blood vessels) and total Heart Failure (HF) events, including HF hospitalization and urgent visits for HF(generally meaning a hospital stay or urgent presentation to a healthcare unit due to worsening symptoms of heart failure) in patients suffering from HF with an ejection fraction greater than or equal to 40%. Researchers will also collect information on how much the heart disease has impact on patient's lives, change of kidney function, and how well finerenone treatment is tolerated. The study plans to enroll 6000 male and female patients of the age of 40 years and above suffering from heart failure with ejection fraction greater than or equal to 40%. Participants will take the study product as oral tablet with a dose between 0 (Placebo) 40 mg once daily. Study duration will be up to 43 months.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (661)

Cardiology, PCBirmingham, Alabama, United States
Eastern Shore Research Institute, LLC | Fairhope, ALFairhope, Alabama, United States
Mobile Heart Specialists - ProvidenceMobile, Alabama, United States
University of Arizona Clinical and Translational Sciences Research CenterTucson, Arizona, United States
Heart Clinic ArkansasLittle Rock, Arkansas, United States
WestSide MedicalBeverly Hills, California, United States
CA Heart and Vein SpecialistsHuntington Beach, California, United States
UCI Medical Center - NeurologyOrange, California, United States
Sutter Medical Center - CardiologySacramento, California, United States
NorthBay Clinical Research, LLC | Santa Rosa, CASanta Rosa, California, United States
The Lundquist Institute - GynecologyTorrance, California, United States
Blue Coast Research Center, LLCVista, California, United States

+ 649 more locations — full list on the registry record.

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