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Study identifier: NCT04432584 Synced from ClinicalTrials.gov · August 02, 2026
● Active Not Recruiting

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors

Condition: Paroxysmal Nocturnal Hemoglobinuria  ·  Sponsor: Hoffmann-La Roche

PhasePhase 3
Planned participants190
Who can joinAll sexes, 2 Years to no upper limit
Healthy volunteersNo

About this study

A study designed to evaluate the safety of crovalimab with eculizumab in participants with PNH currently treated with complement inhibitors. This study will enroll approximately 190 participants.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (80)

Carolinas Healthcare SystemCharlotte, North Carolina, United States
Nationwide Children's HospitalColumbus, Ohio, United States
Cliniques Universitaires Saint-LucBrussels, Belgium
AZ Delta Campus WestlaanRoeselare, Belgium
Chronos Pesquisa ClinicaTaguatinga, Federal District, Brazil
Santa Casa de Misericordia de Porto AlegrePorto Alegre, Rio Grande do Sul, Brazil
Hospital de Clínicas de Porto Alegre XPorto Alegre, Rio Grande do Sul, Brazil
Instituto Joinvilense de Hematologia E OncologiaJoinville, Santa Catarina, Brazil
Hospital das Clínicas FMRP-USPRibeirão Preto, São Paulo, Brazil
*X*CEPHO - Centro de Estudos e Pesquisas em Hematologia e OncologiaSanto André, São Paulo, Brazil
Hospital Sírio-LibanêsSão Paulo, São Paulo, Brazil
Hospital PaulistanoSão Paulo, São Paulo, Brazil

+ 68 more locations — full list on the registry record.

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