Condition: Chronic Obstructive Pulmonary Disease · Sponsor: University Hospital, Grenoble
Acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD) are a major source of morbidity and mortality for patients and cost to the society. In case of acute respiratory failure with hypercapnia and acidosis, Non Invasive Ventilation (NIV) is preferred as a first line treatment. NIV failures are not uncommon, from 15% in intensive care to 25 - 30% in emergency departments. They most often occur at the start of the NIV or in the hours that follow. There are many reasons for these failure. Among these are; dyspnea, discomfort, the pain related to the exacerbation and also to the NIV are frequently noted. The use of certain drugs with anxiolytic, hypnotic and/or analgesic properties could also be useful. Some sedatives and opioids have already been studied in this indication but without a therapeutic trial and satisfactory methodology. Among the molecules of interest, Morphine seems interesting . It's administration could reduce the ventilatory rate, intensity of dyspnea, pain and anxiety as well as dynamic hyperinflation. The investigators believe that morphine administration will decrease the rate of early NIV failure by improving comfort (decreased dyspnea and pain) and ventilation (decreased respiratory rate and increase in tidal volume) in patients with exacerbations of COPD. However, before considering a randomized phase III efficacy study, it is necessary to determine the optimal dose of morphine in this indication, through a phase I/II dose-finding study t…
This description comes directly from the study's public registry record.
Damien VIGLINO, MD, PhD · 0033476766784 · DViglino@chu-grenoble.fr
Prudence MABIALA MAKELE, PhD · 0033476766784 · PMabialamakele@chu-grenoble.fr
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| Emergency Department of Grenoble Alpes University Hospital | Grenoble, Isère, Auvergne-Rhône-Alpes, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04427826