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Study identifier: NCT04323046 Synced from ClinicalTrials.gov · August 05, 2026
● Active Not Recruiting

Immunotherapy Before and After Surgery for Treatment of Recurrent or Progressive High Grade Glioma in Children and Young Adults

Condition: Glioblastoma · Malignant Glioma · Recurrent Glioblastoma  ·  Sponsor: Sabine Mueller, MD, PhD

PhasePhase 1
Planned participants9
Who can joinAll sexes, 6 Months to 25 Years
Healthy volunteersNo

About this study

This phase I trial studies the side effects of nivolumab before and after surgery in treating children and young adults with high grade glioma that has come back (recurrent) or is increasing in scope or severity (progressive). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (20)

University of Alabama at Birmingham, Children's of AlabamaBirmingham, Alabama, United States
Children's Hospital of Los AngelesLos Angeles, California, United States
Rady Children's HospitalSan Diego, California, United States
University of California, San FranciscoSan Francisco, California, United States
Children's National HospitalWashington D.C., District of Columbia, United States
University of FloridaGainesville, Florida, United States
Riley Children's HospitalIndianapolis, Indiana, United States
Johns Hopkins UniversityBaltimore, Maryland, United States
Dana Farber Cancer InstituteBoston, Massachusetts, United States
Washington University St. LouisSt Louis, Missouri, United States
Hackensack Meridian Children's Health at Joseph M. Sanzari Children's HospitalHackensack, New Jersey, United States
Duke Children's Hospital & Health CenterDurham, North Carolina, United States

+ 8 more locations — full list on the registry record.

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