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Study identifier: NCT04320888 Synced from ClinicalTrials.gov · August 03, 2026
● Active Not Recruiting

Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene Alterations, a Pediatric MATCH Treatment Trial

Condition: Hematopoietic and Lymphatic System Neoplasm · Recurrent Ependymoma · Recurrent Ewing Sarcoma  ·  Sponsor: National Cancer Institute (NCI)

PhasePhase 2
Planned participants1
Who can joinAll sexes, 12 Months to 21 Years
Healthy volunteersNo

About this study

This phase II pediatric MATCH treatment trial studies how well selpercatinib works in treating patients with solid tumors that may have spread from where they first started to nearby tissue, lymph nodes, or distant parts of the body (advanced), lymphomas, or histiocytic disorders that have activating RET gene alterations. Selpercatinib may block the growth of cancer cells that have specific genetic changes in an important signaling pathway (called the RET pathway) and may reduce tumor size.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (174)

Children's Hospital of AlabamaBirmingham, Alabama, United States
Providence Alaska Medical CenterAnchorage, Alaska, United States
Banner Children's at DesertMesa, Arizona, United States
Phoenix Childrens HospitalPhoenix, Arizona, United States
Banner University Medical Center - TucsonTucson, Arizona, United States
Arkansas Children's HospitalLittle Rock, Arkansas, United States
Kaiser Permanente Downey Medical CenterDowney, California, United States
City of Hope Comprehensive Cancer CenterDuarte, California, United States
Loma Linda University Medical CenterLoma Linda, California, United States
Miller Children's and Women's Hospital Long BeachLong Beach, California, United States
Children's Hospital Los AngelesLos Angeles, California, United States
Cedars-Sinai Medical CenterLos Angeles, California, United States

+ 162 more locations — full list on the registry record.

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