EICHOR
● Completed
Trial of Treatments for COVID-19 in Hospitalized Adults
Condition: Corona Virus Infection · Sponsor: Institut National de la Santé Et de la Recherche Médicale, France
About this study
DisCoVeRy is a randomized controlled trial among adults (≥18-year-old) hospitalized for COVID-19. This study is an adaptive, randomized, open or blinded, depending on the drug to be evaluated, clinical trial to evaluate the safety and efficacy of possible therapeutic agents in hospitalized adult patients diagnosed with COVID-19. The study is a multi-centre/country trial that will be conducted in various sites in Europe with Inserm as sponsor. The study will compare different investigational therapeutic agents to a control group managed with the SoC including corticosteroids and anticoagulants. There will be interim monitoring to allow early stopping for safety and to introduce new therapies as they become available. If one therapy proves to be superior to others in the trial, this treatment may become part of the SoC for comparison(s) with new experimental treatment(s). In previous versions of the DisCoVeRy protocol, remdesivir, lopinavir/ritonavir with or without interferon ß-1a and hydroxychloroquine were evaluated as potential treatments for COVID-19. These treatments have been discontinued based on analyses review by both DSMC/DSMB, the Solidarity Executive Group and the DisCoVeRy steering committee. This version of the protocol, therefore, describes a randomized blinded placebo-controlled trial among adults (≥18-year-old) hospitalized for COVID-19 that randomly allocates them (1:1 ratio) between 2 arms: SoC + placebo versus SoC + AZD7442. Randomization will be stratif…
This description comes directly from the study's public registry record.
Talk to the study team
No contact information is available for this study as per the public registry record.
Always discuss trial participation with your own doctor first.
Locations (62)
| Medizinische Universität Innsbruck | Innsbruck, Austria | — |
| Kepler Universitätsklinikum Linz | Linz, Austria | — |
| Landeskrankenhaus Salzburg Universitätsklinikum der Paracelsus Medizinischen Privatuniversität | Salzburg, Austria | — |
| Hôpital Erasme - Cliniques universitaires de Bruxelles | Brussels, Belgium | — |
| Hôpital Saint Luc | Brussels, Belgium | — |
| Hôpital La Citadelle | Liège, Belgium | — |
| Pôle Hospitalier Jolimont / site de Mons-Warquignies | Mons, Belgium | — |
| Centre Hospitalier Universitaire Amiens-Picardie | Amiens, France | — |
| Centre Hospitalier Regional Metz-Thionville | Ars-Laquenexy, France | — |
| Centre Hospitalier Régional Universitaire de Besançon | Besançon, France | — |
| Centre Hospitalier Universitaire de Bordeaux | Bordeaux, France | — |
| CHU APHP Ambroise-Paré | Boulogne-Billancourt, France | — |
+ 50 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04315948