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Study identifier: NCT04257877 Synced from ClinicalTrials.gov · July 29, 2026
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Proteomic Analysis in Paediatric Diabetes Type 1 (PAPD)

Condition: Diabetes Type 1 · Proteomics · Diabetic Peripheral Neuropathy  ·  Sponsor: Aristotle University Of Thessaloniki

PhaseN/A
Planned participants50
Who can joinAll sexes, 5 Years to 10 Years
Healthy volunteersYes

About this study

The aim of the present study is to investigate a targeted proteomic analysis in plasma of children - of Greek origin- with type 1 diabetes (DT1) and its correlation with the electrophysiological findings that accompany diabetic peripheral neuropathy. Diabetic neuropathy is the most frequent chronic complication in adults with DT1 and rarely appears in childhood. Nevertheless, cases of acute mononeuritis have been described at the time of diagnosis of DT1. According to recent reports several biomarkers, including proteomic analysis, have been proposed for the early detection of peripheral neuropathy in children and young adults with T1DM. In the present study the researchers will attempt to investigate the role of biomarkers with targeted proteomic analysis in the plasma of children with DT1 in combination with an electrophysiological study, which includes a nerve conduction study, to detect early diabetic peripheral neuropathy, before the appearance of clinical manifestations.

This description comes directly from the study's public registry record.

Talk to the study team

Assimina Galli-Tsinopoulou, MD,PhD  ·  +302310991537  ·  agalli@auth.gr

Eleni Litou, MD  ·  +302313323920  ·  eleni.li.87@gmail.com

Always discuss trial participation with your own doctor first.

Locations (1)

Unit of Pediatric Endocrinology, Diabetes and Metabolism-2nd Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of ThessalonikiThessaloniki, GreeceRecruiting

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Source record: clinicaltrials.gov/study/NCT04257877