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Study identifier: NCT04222972 Synced from ClinicalTrials.gov · August 02, 2026
● Terminated

A Study of Pralsetinib Versus Standard of Care for First-Line Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC)

Condition: RET-fusion Non Small Cell Lung Cancer · Lung Neoplasm · Carcinoma, Non-Small-Cell Lung  ·  Sponsor: Hoffmann-La Roche

PhasePhase 3
Planned participants223
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is an international, randomized, open-label, Phase 3 study designed to evaluate whether the potent and selective RET inhibitor, pralsetinib, improves outcomes when compared to a platinum chemotherapy-based regimen chosen by the Investigator from a list of standard of care treatments, as measured primarily by progression free survival (PFS), for participants with RET fusion-positive metastatic NSCLC who have not previously received systemic anticancer therapy for metastatic disease.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (74)

Hospital BritanicoBuenos Aires, Argentina
Centro Oncologico Riojano Integral (CORI)La Rioja, Argentina
Royal North Shore HospitalSt Leonards, New South Wales, Australia
UZ AntwerpenEdegem, Belgium
Hospital Sao Lucas - PUCRSPorto Alegre, Rio Grande do Sul, Brazil
Hospital A. C. CamargoSão Paulo, São Paulo, Brazil
Clinica CIMCASan José, Costa Rica
Institut Bergonie CLCC BordeauxBordeaux, France
Hôpital Ambroise Paré - Boulogne-BillancourtBoulogne-Billancourt, France
Hôpital Louis Pradel, Hospices Civils de LyonBron, France
CHRU Lille Service de Pneumologie et Oncologie ThoraciqueLille, France
Institut Paoli CalmettesMarseille, France

+ 62 more locations — full list on the registry record.

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