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Study identifier: NCT04194775 Synced from ClinicalTrials.gov · August 05, 2026
● Active Not Recruiting

A Study of Nofazinlimab (CS1003) in Subjects With Advanced Hepatocellular Carcinoma

Condition: Hepatocellular Carcinoma  ·  Sponsor: CStone Pharmaceuticals

PhasePhase 3
Planned participants534
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a multi-center, double-blind, randomized, phase III study to investigate the efficacy and safety of Nofazinlimab (CS1003) in combination with lenvatinib and placebo in combination with lenvatinib in the treatment of subjects with no prior systemic treatment and with unresectable advanced hepatocellular carcinoma (HCC). Subjects cannot be eligible for locoregional therapy. In this study, Nofazinlimab (CS1003) (or placebo) and lenvatinib are both considered as the study treatment while Nofazinlimab (CS1003) (or placebo) is the investigational product and lenvatinib is selected as the basic treatment for HCC.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

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Locations (74)

Southern California Research CenterCoronado, California, United States
Inland Empire Liver FoundationRialto, California, United States
Mercy Medical CenterBaltimore, Maryland, United States
UMass Memorial Medical CenterWorcester, Massachusetts, United States
Stony Brook University Cancer Clinical TrialsStony Brook, New York, United States
The First Affiliated Hospital of Bengbu Medical CollegeBengbu, Anhui, China
The First Affiliated Hospital Of Anhui Medical UniversityHefei, Anhui, China
The Second Affiliated Hospital of Anhui Medical UniversityHefei, Anhui, China
Beijing Cancer HospitalBeijing, Beijing Municipality, China
Beijing You'an Hospital, Capital Medical UniversityBeijing, Beijing Municipality, China
Peking Union Medical College HospitalBeijing, Beijing Municipality, China
The 900th Hospital of Joint Logistic Support Force of PLAFuzhou, Fujian, China

+ 62 more locations — full list on the registry record.

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