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Study identifier: NCT04175912 Synced from ClinicalTrials.gov · August 02, 2026
● Active Not Recruiting

Testing the Combination of Pevonedistat With Chemotherapy for Bile Duct Cancer of the Liver

Condition: Metastatic Cholangiocarcinoma · Metastatic Hepatocellular Carcinoma · Stage III Hepatocellular Carcinoma AJCC v8  ·  Sponsor: National Cancer Institute (NCI)

PhasePhase 2
Planned participants40
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This phase II trial studies how well pevonedistat alone or in combination with chemotherapy (paclitaxel and carboplatin) works in treating patients with bile duct cancer of the liver. Pevonedistat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Chemotherapy drugs, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This study may help the study doctors find out how well pevonedistat shrinks bile duct cancer of the liver when given alone and when in combination with paclitaxel and carboplatin.

This description comes directly from the study's public registry record.

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No contact information is available for this study as per the public registry record.

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Locations (419)

Anchorage Associates in Radiation MedicineAnchorage, Alaska, United States
Anchorage Radiation Therapy CenterAnchorage, Alaska, United States
Alaska Breast Care and Surgery LLCAnchorage, Alaska, United States
Alaska Oncology and Hematology LLCAnchorage, Alaska, United States
Alaska Women's Cancer CareAnchorage, Alaska, United States
Anchorage Oncology CentreAnchorage, Alaska, United States
Katmai Oncology GroupAnchorage, Alaska, United States
Providence Alaska Medical CenterAnchorage, Alaska, United States
Kingman Regional Medical CenterKingman, Arizona, United States
Cancer Center at Saint Joseph'sPhoenix, Arizona, United States
CHI Saint Vincent Cancer Center Hot SpringsHot Springs, Arkansas, United States
Mission Hope Medical Oncology - Arroyo GrandeArroyo Grande, California, United States

+ 407 more locations — full list on the registry record.

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