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Study identifier: NCT04165772 Synced from ClinicalTrials.gov · August 04, 2026
● Recruiting

Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors

Condition: Rectal Adenocarcinoma · Clinical Stage: Stage II (T3-4, N-) · Stage III (Any T, N+)  ·  Sponsor: Memorial Sloan Kettering Cancer Center

PhasePhase 2
Planned participants212
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to find out whether the study drug, TSR-042, followed by standard chemoradiotherapy (the chemotherapy drug capecitabine + radiation therapy) and standard surgery is an effective treatment for advanced dMMR solid tumors. The study will also look at the safety of the study drug.

This description comes directly from the study's public registry record.

Talk to the study team

Andrea Cercek, MD  ·  646-888-4189  ·  cerceka@mskcc.org

Neil Segal, MD, PhD  ·  646-888-4187

Always discuss trial participation with your own doctor first.

Locations (10)

Hartford Healthcare (Data Collection)Hartford, Connecticut, United StatesRecruiting
Baptist Alliance MCI (Data Collection Only)Miami, Florida, United StatesRecruiting
Memorial Sloan Kettering Basking Ridge - Limited Protocol ActivitiesBasking Ridge, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Monmouth - Limited Protocol ActivitiesMiddletown, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Bergen - Limited Protocol ActivitiesMontvale, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Commack - Limited Protocol ActivitiesCommack, New York, United StatesRecruiting
Memorial Sloan Kettering Westchester - Limited Protocol ActivitiesHarrison, New York, United StatesRecruiting
Memorial Sloan Kettering Cancer CenterNew York, New York, United StatesRecruiting
Memorial Sloan Kettering Nassau - Limited Protocol ActivitiesUniondale, New York, United StatesRecruiting
Lehigh Valley Health Network (Data Collection Only)Allentown, Pennsylvania, United StatesRecruiting

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